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CyFlow™ CD4 PE

CyFlow™ CD4 PE
Antigen: CD4
Alternative Name: Leu3a, T4
Clone: OX-35
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Rat
Field of Interest: Immunophenotyping, MHC
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG2a
Order number: BU785433

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 230.00 EUR*

Prices net excl. VAT, plus applicable shipping costs

Concentration 0.5 mg/ml Quantity 0.1 mg Volume 0.2 ml Immunogen MLR generated rat... more
CyFlow™ CD4 PE
Concentration0.5 mg/ml
Quantity0.1 mg
Volume0.2 ml
ImmunogenMLR generated rat Th cells
SpecifityThe mouse monoclonal antibody OX-35 recognizes an extracellular epitope of rat CD4 transmembrane glycoprotein (55 kDa).
Background InformationCD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands, such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation, T/B-cell adhesion, T-cell differenciation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).
UsageThe reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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