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CyFlow™ CD11b PE

CyFlow™ CD11b PE
Antigen: CD11b
Alternative Name: Mac-1
Clone: M1/70
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Human, Mouse, Non-Human Primates, Rabbit
Field of Interest: Immunophenotyping, MHC
Species of Origin: Rat
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG2b
Order number: AL816358

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 0.5 mg/ml Quantity 0.1 mg Volume 0.2 ml Immunogen B10 mouse spleen... more
CyFlow™ CD11b PE
Concentration0.5 mg/ml
Quantity0.1 mg
Volume0.2 ml
ImmunogenB10 mouse spleen cells enriched for T cells
SpecifityThe rat monoclonal antibody M1/70 recognizes CD11b antigen, a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions.
Background InformationCD11b (integrin αM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with CD18 (integrin β2 subunit); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
UsageThe reagent is designed for Flow Cytometry analysis. Suggested working usage is 0.5·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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