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CyFlow™ CD19 Purified

CyFlow™ CD19 Purified
Antigen: CD19
Alternative Name: B4
Clone: 4G7
Application: Flow cytometry, Immunocytochemistry
Format/Fluorochrome: Purified
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: BS738572

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 140.00 EUR*

Prices net excl. VAT, plus applicable shipping costs

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen Human CCL (chronic... more
CyFlow™ CD19 Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenHuman CCL (chronic lymphocytic leukemia) cells
SpecifityThe mouse monoclonal antibody 4G7 recognizes CD19 antigen, a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Background InformationCD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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