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CyFlow™ CD42a FITC

CyFlow™ CD42a FITC
Antigen: CD42a
Alternative Name: GPIX
Clone: GR-P
Application: Flow cytometry
Format/Fluorochrome: FITC
Laser: Blue
Target Species: Dog, Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 518 nm
Excitation Maximum: 490 to 495 nm
Isotype: IgG1
Order number: CG796648

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 180.00 EUR*

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*1
*1 Offer valid until 31/10/2017
HLDA Workshop HLDA IV—WS Code P 35 Quantity 100 tests Volume 0.4 Immunogen Human... more
CyFlow™ CD42a FITC
HLDA WorkshopHLDA IV—WS Code P 35
Quantity100 tests
Volume0.4
ImmunogenHuman Acute Lymphocytic Leukemia (ALL) T cells
Background InformationCD42a (GPIX; Glycoprotein 9) composes together with GPIb α, GPIb β and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Knapp W, Dorken B, Gilks W, Rieber EP, Schmidt RE, Stein H, von dem Borne AEGK (Eds): Leucocyte Typing IV. Oxford·University·Press,·Oxford. 1989; 1‑1820. <·NLM·ID:·8914679·> | Brown SB, Clarke MC, Magowan L, Sanderson H, Savill J: Constitutive death of platelets leading to scavenger receptor‑mediated phagocytosis: A caspase‑independent cell clearance program. J·Biol·Chem. 2000·Feb·25; 275(8):5987‑96. <·PMID:·10681593·> | Harding SA, Din JN, Sarma J, Josephs DH, Fox KA, Newby DE: Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin. Heart. 2006·Nov; 92(11):1635‑8. <·PMID:·16709700·> | Vettore S, Scandellari R, Moro S, Lombardi AM, Scapin M, Randi ML, Fabris F: Novel point mutation in a leucine‑rich repeat of the GPIb alpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard‑Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica. 2008·Nov; 93(11):1743‑7. <·PMID:·18815197·> | Din JN, Aftab SM, Jubb AW, Carnegy FH, Lyall K, Sarma J, Newby DE, Flapan AD: Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans. Eur·J·Clin·Nutr. 2011·Feb; 65(2):234‑9. <·PMID:·21048773·>