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CyFlow™ CD44 PerCP-Cy5.5

CyFlow™ CD44 PerCP-Cy5.5
Antigen: CD44
Alternative Name: H-CAM, Pgp-1
Clone: IM7
Application: Flow cytometry
Format/Fluorochrome: PerCP-Cy5.5
Laser: Blue, Green
Target Species: Cat, Dog, Horse, Human, Mouse
Field of Interest: Immunophenotyping
Species of Origin: Rat
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 695 nm
Excitation Maximum: 482 nm
Isotype: IgG2b
Order number: BM575398

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 0.5 mg/ml Quantity 0.1 mg Volume 0.2 ml Immunogen... more
CyFlow™ CD44 PerCP-Cy5.5
Concentration0.5 mg/ml
Quantity0.1 mg
Volume0.2 ml
ImmunogenDexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
SpecifityThe rat monoclonal antibody IM7 recognizes CD44 antigen, an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.
Background InformationCD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumor growth and metastasis, antiapoptosis and directional motility of cancer cells.
UsageThe reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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