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CyFlow™ CD45RA PerCP

CyFlow™ CD45RA PerCP
Antigen: CD45RA
Alternative Name: Leu18
Clone: MEM-56
Application: Flow cytometry
Format/Fluorochrome: PerCP
Laser: Blue, Green
Target Species: Human
Field of Interest: Immunophenotyping, Phosphorylation
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 678 nm
Excitation Maximum: 482 to 490 nm
Isotype: IgG2b
Order number: BN724072

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 230.00 EUR*

Prices net excl. VAT, plus applicable shipping costs

Quantity 100 tests Volume 1 ml Immunogen Human thymocytes and T lymphocytes... more
CyFlow™ CD45RA PerCP
Quantity100 tests
Volume1 ml
ImmunogenHuman thymocytes and T lymphocytes
SpecifityThe mouse monoclonal antibody MEM-56 recognizes CD45RA antigen, a 205-220 kDa single chain type I glycoprotein, isoform of the leukocyte common antigen (LCA). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.
Background InformationCD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naive T cells and normal plasma cells.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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