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CyFlow™ CD50 Low Endotoxin

CyFlow™ CD50 Low Endotoxin
Antigen: CD50
Alternative Name: ICAM-3
Clone: MEM-04
Application: Flow cytometry, Functional assays, Immunohistochmistry (paraffin-embedded sections)
Format/Fluorochrome: Low Endotoxin
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: AS684336

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 140.00 EUR*

Prices net excl. VAT, plus applicable shipping costs

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen Leukocytes of a... more
CyFlow™ CD50 Low Endotoxin
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenLeukocytes of a patient suffering from LGL-type Leukemia
SpecifityThe mouse monoclonal antibody MEM-04 recognizes CD50 antigen, a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
Background InformationCD50 ( ICAM-3; intracellular adhesion molecule 3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (DC-SIGN; dendritic cell-specific ICAM-3-grabbing nonintegrin), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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