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CyFlow™ CD79a PerCP-Cy5.5

CyFlow™ CD79a PerCP-Cy5.5
Antigen: CD79a
Alternative Name: IgA, MB-1, MB1
Clone: HM47
Application: Flow cytometry
Format/Fluorochrome: PerCP-Cy5.5
Laser: Blue, Green
Target Species: Chicken, Cow, Dog, Guinea pig, Horse, Human, Mouse, Non-Human Primates, Pig, Rabbit, Rat
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 695 nm
Excitation Maximum: 482 nm
Isotype: IgG1
Order number: BP912385

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Quantity 100 tests Volume 0.4 ml Immunogen Synthetic peptide corresponding to C... more
CyFlow™ CD79a PerCP-Cy5.5
Quantity100 tests
Volume0.4 ml
ImmunogenSynthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
SpecifityThe mouse monoclonal antibody HM57 recognizes CD79a, a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
Background InformationCD79a (Ig α, MB1) forms disulfide-linked heterodimer with CD79b (Ig β, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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