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CyFlow™ CD4 PerCP

CyFlow™ CD4 PerCP
Application: Flow cytometry
Format/Fluorochrome: PerCP
Clone: GK1.5
Alternative Name: Leu3a, T4
Antigen: CD4
Emission Maximum: 678 nm
Excitation Maximum: 482 to 490 nm
Field of Interest: Immunophenotyping, MHC
Clonality: monoclonal
Target Species: Mouse
Laser: Blue, Green
Isotype: IgG2b
Regulatory Status: RUO
Source Species: Rat
Order number: AJ556990
230,00  EUR *

Prices net excl. VAT, plus applicable shipping costs

Delivery time appr. 3-5 workdays

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CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its... more
Produktinformationen zu: "CyFlow™ CD4 PerCP"
CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands, such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).

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Technical Data Sheet

Instruction for Use

ECDoC

Certificate Of Analysis

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* All prices are quoted net of the statutory value-added tax and shipping costs and possibly delivery charges, if not otherwise described

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