Welcome to
Sysmex Flow Cytometry Germany!

For ordering please make sure you are in your local shop.
If you are from Germany then please continue.
Otherwise please go to your country.

Go to my country Continue

CyFlow™ CD45RA Biotin

CyFlow™ CD45RA Biotin
Antigen: CD45RA
Alternative Name: Leu18
Clone: MEM-56
Application: Flow cytometry
Format/Fluorochrome: Biotin
Target Species: Human
Field of Interest: Immunophenotyping, Phosphorylation
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG2b
Order number: BC517380

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 200.00 EUR*

Prices net excl. VAT, plus applicable shipping costs

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen Human thymocytes... more
CyFlow™ CD45RA Biotin
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenHuman thymocytes and T lymphocytes
SpecifityThe mouse monoclonal antibody MEM-56 recognizes CD45RA antigen, a 205-220 kDa single chain type I glycoprotein, isoform of the leukocyte common antigen (LCA). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.
Background InformationCD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naive T cells and normal plasma cells.
UsageThe reagent is designed for indirect immunofluorescence analysis by Flow Cytometry. Suggested working usage is 8.3·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
Storage BufferThe reagent is provided in Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Article successfully added.