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CyFlow™ CD64 Purified

CyFlow™ CD64 Purified
Antigen: CD64
Alternative Name: FcγRI
Clone: 10.1
Application: Flow cytometry, Functional assays, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western blot
Format/Fluorochrome: Purified
Target Species: Human, Non-Human Primates
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: CV129072

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

 140.00 EUR*

Prices net excl. VAT, plus applicable shipping costs

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen Rheumatoid synovial... more
CyFlow™ CD64 Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenRheumatoid synovial fluid cells and fibronectin purified human monocytes
SpecifityThe mouse monoclonal antibody 10.1 recognizes α subunit of CD64 antigen, a 72 kDa single chain type I glycoprotein, that is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes.
Background InformationCD64 (FcγRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding α subunit and promiscuous γ subunit, which is indispensable for tyrosine-based signaling. However, even the α subunit can transduce signals leading to cellular effector functions. The isoform FcγRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcγRIb and FcγRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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